Although
hypothyroidism this is a site in which the thyroid gland does not produce
enough thyroid hormone -which is common in hemodialysis
( Kidney) patients, it's
unclear how it affects their health and quality of life
Increase of
thyrotropin levels may effect multiple areas of health-related quality of life,
including energy/fatigue, physical function, and pain.
"Given the high
prevalence of thyroid dysfunction and low levels of quality of life in dialysis
patients, Many research is needed to determine the underlying mechanisms of
these associations, and whether replacement of thyroid hormone can improve the
health-related quality of life of this population. "In addition, as the
first study in dialysis patients to document an association between higher
thyrotropin levels and low levels of physical function, a strong predictor of
death, future studies are needed to determine whether correction of thyroid
status with exogenous thyroid hormone can improve physical function in this
population."
Sickle cell disease, a blood disorder, can impact the function of the
kidneys, and the earliest sign of kidney damage in affected patients is
albuminuria, or the presence of albumin in the urine
Hydroxyurea (HU),
which makes red blood cells more flexible, is one of the cornerstones of sickle
cell disease treatment, but its effects on kidney
function are unclear. Adults with sickle cell
disease who were starting HU therapy. After 6 months of treatment, patients'
kidney function, as measured by the urinary albumin/creatine ratio, improved
significantly.
"The findings
offer further evidence, albeit not yet definitive, of a potential renal benefit
of HU, and should strengthen arguments favoring its use in sickle cell disease
for other indications and encouraging patient adherence to this drug,"
"Our preliminary results require additional larger, prospective,
randomized, controlled trials to clearly demonstrate the positive effect of HU
to reduce albuminuria levels and delay chronic kidney disease
progression,"
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